Synonymer & Information om | Engelska ordet AUTOANTIGEN

Exempel på hur man kan använda AUTOANTIGEN i en mening

• GAD, a presynaptic autoantigen, is generally thought to play a key role in the condition, but exact details of the way autoantibodies affect SPS patients are not known.
• Citrullinated vimentin may be an autoantigen in RA and other autoimmune diseases, and is used to study RA.
• This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate (HGS).
• This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
• Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.
• The main autoantigen of dermatitis herpetiformis is epidermal transglutaminase (eTG), a cytosolic enzyme involved in cell envelope formation during keratinocyte differentiation.
• Autoantigenic peptides containing citrulline residues are preferentially bound by HLA-DRB SE proteins and are presented to T cells, which interact with CCP-specific B cells found at sites containing autoantigen and produce inflammatory cytokines and autoantibodies, which accelerate disease.
• Falk’s seminal work published in the 1988 article in the New England Journal of Medicine described the discovery that ANCA vasculitis is an autoimmune disease with increased expression of the autoantigen genes, myeloperoxidase (MPO) and proteinase 3 (PRTN3) To clarify this, in 2020 Falk and colleagues measured MPO and PRTN3 messenger RNA in monocytes, normal-density neutrophils, and in enriched leukocytes from peripheral blood mononuclear cells.
• Following MD studies at Tel Aviv University, military service as a medical officer (Major) in the IDF and residency in Pediatrics at Sheba Medical Center, Birk did his PhD at the Weizmann Institute with Irun Cohen, delineating hsp60 as a crucial autoantigen in type 1 diabetes and allograft rejection, effective in their prevention.
• This work has allowed detailed analysis of how celiac antibodies recognize the autoantigen, and it has enabled the establishment of a mouse model to study autoantibody formation to transglutaminase 2.

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