Synonymer & Anagram | Engelska ordet AUTOCRINE

Exempel på hur man kan använda AUTOCRINE i en mening

• Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents.
• However, it also contains traits of autocrine signaling: a cell produces both an autoinducer molecule and the receptor for the autoinducer.
• Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to cell signaling by endocrine factors, hormones which travel considerably longer distances via the circulatory system; juxtacrine interactions; and autocrine signaling.
• Like cAMP, cGMP is an important second messenger that internalizes the message carried by intercellular messengers such as peptide hormones and nitric oxide and can also function as an autocrine signal.
• Leukotrienes use lipid signaling to convey information to either the cell producing them (autocrine signaling) or neighboring cells (paracrine signaling) in order to regulate immune responses.
• IL-10 may autoregulate its expression via a negative feed-back loop involving autocrine stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway.
• Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine).
• In mature animals, where survival factors are derived locally or via autocrine loops, axotomy of peripheral neurons and motoneurons can lead to a robust regenerative response without any neuronal death.
• It is a critical autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts.
• Both the overexpression of Met/HGFR, as well as its autocrine activation by co-expression of its hepatocyte growth factor ligand, have been implicated in oncogenesis.
• The biological effects produced by intracellular actions are referred as intracrine effects, whereas those produced by binding to cell surface receptors are called endocrine, autocrine, or paracrine effects, depending on the origin of the hormone.
• Cell signaling can occur over short or long distances, and can be further classified as autocrine, intracrine, juxtacrine, paracrine, or endocrine.
• These growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth factor, insulin-like growth factor, hepatocyte growth factor, and platelet-derived endothelial growth factor.
• A study also demonstrated how the autocrine production of the IL-7 cytokine mediated by T-cell acute lymphoblastic leukemia (T-ALL) can be involved in the oncogenic development of T-ALL and offer novel insights into T-ALL spreading.
• Somatomedins are produced in many tissues and have autocrine and paracrine actions in addition to their endocrine action.
• These cells are responsive to both autocrine and paracrine activin B signaling, which controls their proliferation.
• In fibroblasts, IL-11 drives an ERK-dependent autocrine loop of fibrogenic protein synthesis that is at a nexus of fibrotic signalling and required for the pro-fibrotic activity of TGFB1, PDGF, endothelin1, angiotensin and many other pro-fibrotic factors.
• IL-30 was identified as a cytokine able to condition, in an autocrine or paracrine manner, gene expression profile, at times the viability, motility, and invasiveness of breast cancer cells and to generate an inflammatory and prometastatic milieu supporting tumor growth and progression.
• CCL1 is also overexpressed in ATL cells and mediates an autocrine antiapoptotic loop along CCR8 for in vivo growth and survival of leukemic cells.
• This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption.

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