Information om | Engelska ordet AUTOINFLAMMATORY

Exempel på hur man kan använda AUTOINFLAMMATORY i en mening

• FMF is an autoinflammatory disease caused by mutations in Mediterranean fever gene, which encodes a 781–amino acid protein called pyrin.
• The orange and red-orange tones of the official logo and ribbon represent inflammation and fevers, which are prevalent in flare-ups of autoinflammatory diseases.
• Several pioneering medical innovations have been made by UC San Diego researchers, such as the development of the chemotherapy drug cetuximab, the use of gene therapy in the treatment of congenital defects, the discovery of insulin resistance as a cause of diabetes, the understanding of genetic blood disorders such as sickle cell disease, the link between vitamin D deficiency and certain cancers, the first human trials of robotically assisted laparoscopic surgery, the development of the first oral drug for treating interstitial cystitis called Elmiron, the demonstration of HIV latency, the link between the p53 gene and rheumatoid arthritis, the identification of the genetic basis for familial cold autoinflammatory syndrome, the discovery of an early warning sign for autism, the connection between inflammation and cancer, the use of green fluorescent protein as a surgical and research aid, the nation's first sleeve gastrectomy, and the discovery of a potential treatment for chronic lymphomatic leukemia called Cirmtuzumab.
• A rare syndromic association called pyogenic arthritis, pyoderma gangrenosum and acne syndrome (PAPA syndrome), a type of autoinflammatory disorder, is associated with mutations in the proline-serine-threonine phosphatase-interacting 1 gene (PSTPIP1).
• Thus, IL-1β has become a common therapeutic target, and medications such as anakinra, rilonacept, and canakinumab have revolutionized the treatment of autoinflammatory diseases.
• Mutations in the NLRP3 gene result in autoactive inflammasomes and have been associated with a spectrum of dominantly inherited autoinflammatory diseases called cryopyrin-associated periodic syndrome (CAPS).
• Mutations in the PSMB8 gene, which encodes the LMP7 subunit, are involved in a variety of diseases and autoinflammatory disorders, the symptoms of which include skin rash, erythema, spiking fever and lipodystrophy, which are presented since early childhood.
• Biallelic deleterious mutations in the IL1RN gene results in a rare autoinflammatory disease called deficiency of the interleukin-1–receptor antagonist (DIRA).
• Food and Drug Administration (FDA) in June 2009, CAPS is a spectrum of autoinflammatory syndromes including Familial Cold Autoinflammatory Syndrome (FCAS), Muckle–Wells syndrome (MWS), and Neonatal-Onset Multisystem Inflammatory Disease (NOMID).
• Hypomorphic mutations in this gene have been associated with host susceptibility to viral infection, while gain-of-function variants can cause autoinflammatory immunodeficiency.
• Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of fevers, joint pain, and a distinctive salmon-colored bumpy rash.
• For instance, patients with a homozygous missense mutation (G197V) in the immunoproteasome subunit, β type 8 (PSMB8) suffered from autoinflammatory responses that included recurrent fever and nodular erythema together with lipodystrophy.
• Schnitzler syndrome is considered an autoinflammatory disorder and is generally treated with anakinra, which inhibits interleukin 1.
• This protein is part of an inflammatory pathway associated with other autoinflammatory diseases such as familial Mediterranean fever, hyperimmunoglobulinemia D with recurrent fever, Muckle–Wells syndrome, neonatal onset multisystem inflammatory disease, and familial cold urticaria.
• It encompasses a spectrum of three clinically overlapping autoinflammatory syndromes including familial cold autoinflammatory syndrome (FCAS, formerly termed familial cold-induced urticaria), the Muckle–Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID, also called chronic infantile neurologic cutaneous and articular syndrome or CINCA) that were originally thought to be distinct entities, but in fact share a single genetic mutation and pathogenic pathway, and keratoendotheliitis fugax hereditaria in which the autoinflammatory symptoms affect only the anterior segment of the eye.
• Urticarial autoinflammatory diseases and urticarial vasculitis (UV) are uncommon but should be taken into consideration in patients who experience recurrent wheals.
• Aeschlimann FA, Batu ED, Canna SW, Go E, Gül A, Hoffmann P, Leavis HL, Ozen S, Schwartz DM, Stone DL, van Royen-Kerkof A, Kastner DL, Aksentijevich I, Laxer RM (2018) A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease.
• 1st Propaedeutic Pathology Clinic and Special Nosology (Autoimmune Rheumatic Diseases Unit) of the National and Kapodestrian University of Athens - Rare systemic autoinflammatory and autoimmune diseases.

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