Anagram & Information om | Engelska ordet COREPRESSORS

Exempel på hur man kan använda COREPRESSORS i en mening

• Binding of thyroid hormone results in a conformational change in helix 12 of the TR transactivation domain, which displaces the corepressors from the receptor/DNA complex.
• Transcription coregulators that activate gene transcription are referred to as coactivators while those that repress are known as corepressors.
• In the absence of corepressors and in the presence of coactivators, transcription factors upregulate gene expression.
• Some synthetic retinoid ligands can bind to SHP's LBD and promote its interaction with LXXLL-containing corepressors using the AF-2 site.
• In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression.
• In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT (NCOR2), and histone deacetylase.
• The ability of nuclear receptors to alternate between activation and repression in response to specific molecular cues, is now known to be attributable in large part to a diverse group of cellular factors, collectively termed coregulators and including coactivators and corepressors.
• In zinc-finger proteins, it commonly forms homodimers with other BTB domains, mediates heteromeric dimerization, and recruits transcriptional corepressors.

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