Information om | Engelska ordet CYTOTOXICITY

Exempel på hur man kan använda CYTOTOXICITY i en mening

• Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity).
• IgG also plays an important role in antibody-dependent cell-mediated cytotoxicity (ADCC) and intracellular antibody-mediated proteolysis, in which it binds to TRIM21 (the receptor with greatest affinity to IgG in humans) in order to direct marked virions to the proteasome in the cytosol;.
• These T cells can then go on to perform effector functions such as macrophage activation, B cell activation, and cell-mediated cytotoxicity.
• In spite of severe in vitro cytotoxicity, ZOE showed relatively good biocompatibility in animal study when ZOE was applied on dentin.
• Nelarabine is a prodrug of arabinosylguanine nucleotide triphosphate (araGTP), a type of purine nucleoside analog, which causes inhibition of DNA synthesis and cytotoxicity.
• Along with amphinase, another leopard frog ribonuclease, Ranpirnase has been studied as a potential cancer and antiviral treatment due to its unusual mechanism of cytotoxicity tested against transformed cells and antiviral activity.
• Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated with decreased intracellular manganese concentration and attenuated cytotoxicity, characterized by the reversal of manganese-reduced glutamate uptake and diminished lactate dehydrogenase (LDH) leakage.
• CAR T cells destroy cells through several mechanisms, including extensive stimulated cell proliferation, increasing the degree to which they are toxic to other living cells (cytotoxicity), and by causing the increased secretion of factors that can affect other cells such as cytokines, interleukins and growth factors.
• 3T3 Neutral Red Phototoxicity Test – An in vitro toxicological assessment test used to determine the cytotoxicity and photo(cyto)toxicity effect of a test article to murine fibroblasts in the presence or absence of UVA light.
• For instance, high concentrations of benzalkonium chloride (BAK) can cause cytotoxicity, cause cell lysis, and reduce tear and mucin production.
• Their activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity.
• Calotropin is similar in structure to two cardiac glycosides which are responsible for the cytotoxicity of Apocynum cannabinum.
• Various diterpenoids, both known and unknown, have been evaluated for cytotoxicity against human tumor cell lines, and so have various neolignans classed as.
• FOL – folinic acid (leucovorin), a vitamin B derivative with multiple applications, which in this context decreases the cytotoxicity of 5-fluorouracil;.
• M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity.
• It is able to catalyze insulin release by deactivating Potassium ATP channels, leading Phylloseptin-PBu peptide is able to act as a potent antidiabetic with a low cytotoxicity risk, proving valuable to potentially treating T2DM.
• However most snake venoms are capable of more than one toxic activity, such as cytotoxicity, myotoxicity, neuro-toxicity, anticoagulant activity and hypotensive effects.
• When ocrelizumab binds to CD20 on B cells, these cells are deleted by antibody-dependent cell-mediated cytotoxicity and, to a lesser extent, complement-dependent cytotoxicity.
• One study uses a 4 hour chromium release assay, which is an assay used to measure the cytotoxicity of T cells and natural killer cells, to measure lysis of the fresh solid tumor cells from 10 cancer patients and found that in all 10 cancer patients the fresh autologous tumor cells were resistant to lysis by PBL with natural killer cells, but were lysed by the LAK cells.
• Of the natural products presently known combretastatin A-4 is the most potent in regards to both tubulin binding ability and cytotoxicity.

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