Anagram & Information om | Engelska ordet DESMIN

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• Its size, structure, and sequence/location of protein motifs is similar to other type III intermediate filament proteins such as desmin, vimentin and glial fibrillary acidic protein.
• GFAP is closely related to the other three non-epithelial type III IF family members, vimentin, desmin and peripherin, which are all involved in the structure and function of the cell's cytoskeleton.
• Type III contains the proteins vimentin, desmin, peripherin and glial fibrillary acidic protein (GFAP).
• On immunohistochemistry, these cells have trilinear coexpression including the epithelial marker cytokeratin, the mesenchymal markers desmin and vimentin, and the neuronal marker neuron-specific enolase.
• Mutations of several other Z-disk related proteins, such as desmin, alfa-B-crystallin and myotilin can cause disorders similar to zaspopathy.
• Immunohistochemical analyses indicate that the cells in NF usually express smooth muscle actin, muscle specific actin, and vimentin proteins but generally do not express CD34, S-100 protein, desmin, trypsin, factor VIII, F4/80, or HLA-DR1 proteins.
• These binding partners suggest that syncoilin acts as a mechanical "linker" between the sarcomere Z-disk (where desmin is localized) and the dystrophin-associated protein complex (where α-dystrobrevin is localized).
• In 1980, synemin was first identified in avian smooth muscle and was initially described as an IF-associated protein due to its colocalization and copurification with desmin and vimentin.
• Sarcomeric proteins have been identified in PKCε signaling complexes, including actin, cTnT, tropomyosin, desmin, and myosin light chain-2; in mice expressing a constitutively-active PKCε, all sarcomeric proteins showed greater association with PKCε, and the cTnT, tropomyosin, desmin and myosin light chain-2 exhibited changes in post-translational modifications.
• The two primary cytoskeletal components of costameres are desmin intermediate filaments and gamma-actin microfilaments.
• Epithelioid sarcomas typically express vimentin, cytokeratins, epithelial membrane antigen, and CD34, whereas they are usually negative for S100, desmin, and FLI1 (FLI-1).
• This protein family consists of over 50 human proteins divided into 5 major classes, the Class I and II keratins, Class III vimentin, GFAP, desmin and the others, the Class IV neurofilaments and the Class V nuclear lamins.
• Immunohistochemical analyses show that the spindle-shaped cells typically express α-smooth muscle actin, calponin, desmin, and CD99 proteins but not S100 protein or glial fibrillary acidic protein.
• Immunohistochemical analyses indicate that the spindle-shaped cells strongly express smooth muscle actin, calponin, and, less commonly, desmin proteins.
• Staining is positive for vimentin, negative for cytokeratin and desmin, and variable for CD34, Factor VIIIa, SMA, MSA and S-100.
• Immunohistochemical analyses of LGFMS tumors shows cells that express: MUC1 (also termed EMA), CD99, and/or bcl-2 proteins in some cases; CD34 and SMA proteins in rare cases; and S100, desmin, caldesmon, cytokeratin, and CD117 proteins in virtually no cases.
• Neoplastic cells in the spindle cell lipoma tentative MFB variant, similar to mammary and non-mammary MFB, express CD34 and desmin and, in 70% of cases, have the 13q14 defect and therefore do not express pRb.
• Immunohistochemistry will yield a positive reaction with a variety of myoid markers, including desmin, myoglobin, myogenin, MYOD1 and muscle specific actin.
• Mesodermal- (brachyury, Nkx2-5, smooth muscle actin, osteocalcin, oil red-(+) lipid droplets, desmin).
• Diagnosis may be aided by immunostaining; endometrial stromal nodules are positive for CD10; leiomyomas are positive for caldesmon and desmin (and sometimes CD10).

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