Information om | Engelska ordet DOWNREGULATES

Exempel på hur man kan använda DOWNREGULATES i en mening

• Normally this interaction upregulates the production of orange pheomelanin and downregulates the production of black eumelanin, however, in the mutated form, this interaction is prevented, resulting in darker coat color than normal.
• Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and hence may explain why aspirin improves glycemic control in type 2 diabetes.
• The first to be discovered was its capability to drive cell proliferation (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation, and stem cell self-renewal.
• Activated Twist upregulates N-cadherin and downregulates E-cadherin, which are the hallmarks of EMT.
• Research efforts have developed a transgenic cassava plant that stably downregulates linamarin production via RNA interference.
• The presence of an antimorphic protein downregulates the transcriptional products normally upregulated by Clock.
• JDP2 induces cell cycle arrest through cyclin D, JDP2 downregulates p53 transcription, which promotes leukemogenesis.
• A corepressor downregulates (or represses) the expression of genes by binding to and activating a repressor transcription factor.
• Mechanistically, it was observed that 14-3-3ζ downregulates IL-1β and upregulates the IL-1 receptor antagonist, which results in arthritis suppression.
• Currently it is thought that IFNg stops T helper cells from committing for example to the Th17 phenotype, stimulates indoleamine 2,3-dioxygenase transcription (kynurenines or kyn pathway) in certain dendritic cells, stimulates cytotoxic T cells, downregulates T cell trafficking and limits their survival.
• Msx2 downregulates E-cadherins and upregulates N-cadherin and vimentin which indicates its role in inducing epithelial mesenchymal transition (EMT).
• SNAI2 downregulates expression of E-cadherin in premigratory neural crest cells; thus, SNAI2 induces tightly bound epithelial cells to break into a loose mesenchymal phenotype, allowing gastrulation of mesoderm in the developing embryo.
• These include covalent linkage of the C-terminus to phosphatidylethanolamine in autophagic membranes, and phosphorylation by protein kinase A, which downregulates its autophagy functions.
• It upregulates S6 kinase, the downstream effector ribosomal protein, and it downregulates the mTOR kinase.
• It is conventionally thought that phosphorylation inactivates or downregulates KCC2, however there is recent evidence to suggest that phosphorylation at different sites on the KCC2 protein determines different regulational outcomes:.
• Ligation of FCGR2B on B cells downregulates antibody production, prevents the membrane organization of BCR and CD19 and promotes apoptosis.
• AMPA, the most widely distributed receptor in the brain, is a tetrameric ionotropic receptor; alterations in equilibrium between constituent subunits are seen in mGlu2/5HT2A antagonist (antipsychotic) administration- GluR2 is seen to be upregulated in the PFC while GluR1 downregulates in response to antipsychotic administration.
• Pxr sRNA is a regulatory RNA which downregulates genes responsible for the formation of fruiting bodies in Myxococcus xanthus.
• Pxr sRNA is a regulatory RNA which downregulates genes responsible for the formation of fruiting bodies in M.
• A published crossover-randomized clinical trial researched the nutraceutical Eriocitrin (Eriomin) in reducing hyperglycemia by increasing glucagon-like peptide 1 and downregulates systemic inflammation.

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