Information om | Engelska ordet DYNEIN

Exempel på hur man kan använda DYNEIN i en mening

• For example, dynein is a multimeric protein complex involving two heavy chains (DHCs), two intermediate chains (ICs), two light-intermediate chains (LICs) and several light chains (LCs).
• Axonemal dynein, found in cilia and flagella, is crucial to cell motility, for example in spermatozoa, and fluid transport, for example in trachea.
• Some biological machines are motor proteins, such as myosin, which is responsible for muscle contraction, kinesin, which moves cargo inside cells away from the nucleus along microtubules, and dynein, which moves cargo inside cells towards the nucleus and produces the axonemal beating of motile cilia and flagella.
• It was shown to be a multiprotein complex and named "dynactin" because of its role in dynein activation.
• Then, motor proteins dynein and kinesin are recruited and actively transport mRNAs to subcellular locations using cytoskeletal networks.
• Zeste white 10 (ZW10) was initially identified as a mitotic checkpoint protein involved in chromosome segregation, and then implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, but it is also important in non-dividing cells.
• Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles.
• Nexin is a proteinous inter-doublet linkage that prevents microtubules in the outer layer of axonemes from moving with respect to one another; otherwise, vesicular transport proteins such as dynein would dissolve the whole structure.
• Moreover, taxanes prevent androgen receptor (AR) signaling by binding cellular microtubules and the microtubule-associated motor protein dynein, thus averting AR nuclear translocation.
• In Chlamydomonas, radial spoke proteins are thought to regulate the activity of dynein and the symmetry of flagellar bending patterns.
• The BBSome links cargo proteins to intraflagellar transport (IFT) machinery, which transports structural components and receptors, with the help of motor proteins dynein and kinesin, from the tip to the base of the primary cilia (anterograde transport) and back (retrograde transport) along ciliary microtubules.
• The genes that currently have evidence to be associated with CMM disorder include DCC (deleted in colorectal carcinoma), DNAL4 (dynein axonemal light chain 4), and RAD51 (recombination protein A).
• The KASH domain proteins cross the outer nuclear membrane and interact with actin filaments, microtubule filaments (through dynein and kinesin motors), intermediate filaments (through spectrin), centrosomes and cytoplasmic organelles.
• In mitosis, unlike dynactin or dynein perturbation that causes mitotic spindle disarrangement and mitotic arrest, dynactin p27/p25 depletion does not affect mitotic spindle formation, pole focusing or dynein/dynactin targeting to kinetochores.
• For movement between different compartments within the cell, vesicles rely on the motor proteins myosin, kinesin (primarily anterograde transport) and dynein (primarily retrograde transport).
• They identified several structures that link the microtubule motors, kinesin and dynein, to vesicles, and they developed procedures to show the function of the linkers when gathering motor proteins to associate with membrane organelles.
• His group solved X-ray crystal structures of the dynein motor domain showing how it generates force to pull cargos along microtubules and reconstituted a recombinant dynein, showing how its processive movement is activated by cofactors/cargo adaptors.
• For example, when mutations occur in dynein, a motor protein that is crucial in maintaining the uniform orientation of axonal neurotubules, the neurotubule polarity in axon becomes mixed.
• Immunostaining of c4orf36 in syncytiotrophoblast cells (STBs) of mid-gestation human embryos showed a dense punctate pattern consistent with that of c4orf36’s fungal protein analog, dynein light chain, which is involved in intracellular cargo transport and other cellular processes.

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