Anagram & Information om | Engelska ordet ETORPHINE

Exempel på hur man kan använda ETORPHINE i en mening

• The human antidote is generally naloxone, not diprenorphine, and is always prepared before the preparation of etorphine to be immediately administered following accidental human exposure to etorphine.
• MVK is an intermediate in the synthesis of some pharmaceutical drugs including etorphine, buprenorphine, tolquinzole, butaclamol, and etretinate.
• There he studied the effects of various sedative drugs on wild African mammals and with a team invented the M-99 (etorphine hydrochloride) capture drug and refined the tranquilliser gun, or 'Capture gun', for darting animals.
• Immobilon, a mixture of etorphine and a phenothiazine drug such as acepromazine or methotrimeprazine.
• These stereoisomers are among the most potent μ-opioid receptor agonists known, comparable to super-potent opioids such as carfentanil and etorphine which are only legally used for tranquilizing large animals such as elephants in veterinary medicine.
• However conventional opioid derivatives are not strong enough to rapidly tranquilize large animals, like elephants and rhinos, so drugs such as etorphine and carfentanil are available for this purpose.
• Several chemicals were proposed, such as the tranquilizer diazepam (Valium), the anticholinergic BZ, the highly potent oripavine-derived Bentley-series opioid etorphine, another highly potent opioid, such as a fentanyl or an analogue thereof, such as 3-methylfentanil, and the anaesthetic halothane.
• Other notable derivatives then result from further modification of this template, with saturation of the 7,8-double bond of etorphine resulting in the even more potent dihydroetorphine (up to 12,000× potency of morphine) and acetylation of the 3-hydroxy group of etorphine resulting in acetorphine (8700× morphine)—although while the isopentyl homologue of etorphine is nearly three times more potent, its 7,8-dihydro and 3-acetyl derivatives are less potent than the corresponding derivatives of etorphine at 11,000 and 1300 times morphine, respectively.
• Acetorphine was developed for the same purpose as etorphine itself, namely as a strong tranquilizer for use in immobilizing large animals in veterinary medicine.
• Because etorphine is used to immobilize large, still moving, animals, it is often administered intramuscularly using a dart whereas cyprenorphine can be administered intravenously in the femoral vein of the immobile animal.

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