Information om | Engelska ordet FLUOROCITRATE

Exempel på hur man kan använda FLUOROCITRATE i en mening

• The metabolite of fluoroacetic acid is Fluorocitric acid and is very toxic because it is not processable using aconitase in the Krebs cycle (where fluorocitrate takes place of citrate as the substrate).
• The fact that fluoroacetate in itself is far less toxic than its metabolite fluorocitrate led him to coin the term "lethal synthesis" which was the title of his Croonian Lecture of 1951.
• This compound reacts with oxaloacetate to form fluorocitrate, which is toxic, being an alternate substrate for aconitase (normal substrate citrate).
• Fluoroacetate is a precursor to fluorocitrate, an inhibitor of aconitase, an enzyme that participates in the TCA cycle.
• Flurocitrate is a metabolite of fluoroacetic acid and is very toxic because it is not processable using aconitase in the citrate cycle (where fluorocitrate takes place of citrate as the substrate).
• Lethal synthesis, or suicide metabolism, is the biosynthesis of a toxin from a precursor which is not itself toxic, such as the synthesis of fluorocitrate from fluoroacetate or the synthesis of methylglyoxal from glycerol.

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