Synonymer & Anagram | Engelska ordet PKA

Exempel på hur man kan använda PKA i en mening

• In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase whose activity is dependent on cellular levels of cyclic AMP (cAMP).
• Increased β-adrenergic stimulation reduces the association between SERCA and PLB by the phosphorylation of PLB by PKA.
• During an action potential, synapsins are phosphorylated by PKA (cAMP dependent protein kinase), releasing the synaptic vesicles and allowing them to move to the membrane and release their neurotransmitter.
• In a number of systems, VIP binding activates adenyl cyclase activity leading to increases in cAMP and PKA.
• Immediately after the end of the war, there were four such stations in the Dutch East Indies, and these were all designated with callsigns in the new PK series: PKA Sabang, PKB Weltevreden, PKC Sitoebondo, and PKD Koepang'.
• Their main targets are protein kinases as PKA and PKG, being then involved in phosphorylation mediated responses.
• Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation), may enhance the rate of cardiac myocyte relaxation.
• At low blood glucose concentrations, glucagon triggers a cAMP signal cascade and in turn, Protein Kinase A (PKA) phosphorylates Serine 32 near the N-terminus.
• Glycogen synthase is directly regulated by glycogen synthase kinase 3 (GSK-3), AMPK, protein kinase A (PKA), and casein kinase 2 (CK2).
• Vasodilation – PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in MLC of myosin being dephosphorylated by MLCP and thus inhibiting contraction.
• In kickboxing, Jackson defeated among others, Ricci Wynn, Miguel Sanders, Sam Montgomery, Ray McCallum, Jerry Galarza, Tabata, and Toshio Arima to become the 1980 number one world contender in both the WKA and the PKA.
• This PKA will phosphorylate many components of the cardiomyocyte such as calcium channels and components of the myofilaments.
• Adenylyl cyclase then catalyzes the conversion of ATP to cyclic AMP (cAMP), which activates downstream effectors such as Protein Kinase A (PKA).
• Serines occupying positions 81, 222, 276, 433, 492 and 517 act as phosphorylation sites -numbered from 1 to 6- for PKA, as well as several other threonines and serines which add up to 27 phosphorylation sites.
• The production of PKA results in the phosphorylation of phospholamban and inhibition of its block on the sarcoendoplasmic reticulum calcium ATPase (SERCA).
• Through the 1970s, the PKA was the largest and most successful professional kickboxing organization in the United States and in the UK and much of Europe, featuring such fighters as Bill "Superfoot" Wallace, Joe Lewis, Benny "the Jet" Urquidez, The Iceman Jean-Yves Thériault, Dennis "the Terminator" Alexio, Rick "the Jet" Roufus, Jerry Trimble and Jeff Smith.
• In phagocytes, most of the bactericidal functions are stopped by cAMP-mediated activation of PKA and Epac.
• Its activity is also regulated by posttranslational modification caused by phosphorylation by different kinases, like MAPK, CDC2, PKA or PKC which influence protein stability, DNA-binding activity and the trans-activating potential of the transcription factors.
• It is PKA, activated by a hormone-induced signal transduction cascade, that phosphorylates and activates hormone sensitive lipase (HSL), hence the name.
• In addition, during differentiation of neuroblastoma cells, it has been shown that a protein kinase A (PKA) activator will increase the quantity of NAAG, while a protein kinase C (PKC) activator will decrease its concentration.

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