Synonymer & Information om | Engelska ordet PLASMINOGEN

Exempel på hur man kan använda PLASMINOGEN i en mening

• Although plasminogen cannot cleave fibrin, it still has an affinity for it, and is incorporated into the clot when it is formed.
• Angiostatin is a 38 kDa fragment of a larger protein, plasmin (itself a fragment of plasminogen) enclosing three to five contiguous kringle modules.
• Tissue-type plasminogen activator, short name tPA, is a protein that facilitates the breakdown of blood clots.
• Plasmin is released as a zymogen called plasminogen (PLG) from the liver into the systemic circulation.
• Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals.
• Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA).
• In vitro data suggest that activated protein C exerts an antithrombotic effect by inhibiting factors Va and VIIIa, and that it has indirect profibrinolytic activity by inhibiting plasminogen activator inhibitor-1 (PAI-1).
• Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor (serpin E1) is a protein that in humans is encoded by the SERPINE1 gene.
• It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen.
• Like other vampire bats, their saliva contains plasminogen activators, which rapidly dissolves the host's blood clots that form during feeding; platelet aggregation inhibitors, which prevent the formation of blood clots; and other anticoagulants.
• thumbPlasminogen activators are serine proteases that catalyze the activation of plasmin via proteolytic cleavage of its zymogen form plasminogen.
• Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein(a).
• patent for the first human protein manufactured using genetic recombination, with a process for creating an rtPA recombinant tissue plasminogen activator for dissolving blood clots.
• Desmoteplase is a recombinant form of the alpha-1 isoform of DSPA (Desmodus rotundus salivary plasminogen activator).
• Over 150 cerebroprotectants have been tested in clinical trials, leading to the approval of tissue plasminogen activator (also known as tPA, t-PA, rtPA, Activase, or Alteplase or Actilyse) in the US and other countries, and edaravone (Radicut) in Japan.
• In increasing numbers of primary stroke centers, pharmacologic thrombolysis with the drug tissue plasminogen activator (tPA), is used to dissolve the clot and unblock the artery.
•  schlegeli venom are phospholipase A2 related to the production of edema, tissue damage and myotoxicity, metalloproteases with dermonecrosis, L-amino acid oxidases with tissue damage, serine proteases with tissue damage and hemorrhagic diathesis, lectin type C with tissue damage and hemorrhagic diathesis, disintegrins with detachment of cells from their extracellular matrix leading to blisters and platelet function impairment, bradykinin-potentiating peptides with hypotension, enzymes that degrade fibrinogen, plasminogen activators, prothrombin activators, factor V activators, factor X activators, and anticoagulant activities (including inhibitors of prothrombinase complex formation, inhibitors of thrombin, phospholipases, and protein C activators).
• Soluble urokinase plasminogen activator receptor (suPAR) has been found to be a biomarker of inflammation.
• Recently, moonlighting functions of several enolases, such as interaction with plasminogen, have brought interest to the enzymes' catalytic loops and their structural diversity.
• Another hypothesis argues that streptokinase (produced by killed bacteria of species Streptococcus pyogenes together with plasminogen from the patient) is the active agent of Coley's toxins.

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