Anagram & Information om | Engelska ordet TCRS

Exempel på hur man kan använda TCRS i en mening

• Junctional diversity occurs during recombination and serves to further increase the diversity of BCRs and TCRs.
• The Selection model suggests that MHC restriction is not a hard-wired property in the Germline sequences of TCRs, but imposed on them by CD4 and CD8 co-receptors during positive selection.
• These phosphatases inhibit activation of molecules involved in cell signaling, most commonly by binding to activating receptors including TCRs, BCRs and FcRs.
• The variable region of antigen receptors of T cells (TCRs) and B cells (immunoglobulins) contain complementarity-determining regions (CDRs) with unique amino acid sequences.
• These TCRs, capable of cross-restriction across multiple HLA-DR alleles, can confer enhanced antigen sensitivity and polyfunctionality when transferred to healthy T cells, suggesting their potential role in immunotherapeutic strategies for HIV.
• Once an adaptive response has been mounted against one type of flagellin, or if a previous encounter has left the adaptive immune system ready to deal with one type of flagellin, switching types renders previously high affinity antibodies, TCRs, and BCRs ineffective against the flagella.
• ImmTACs (Immune mobilising monoclonal T-cell receptors Against Cancer) are a class of bispecific biological drug being investigated for the treatment of cancer and viral infections which combines engineered cancer-recognizing TCRs with immune activating complexes.
• Garcia's group has also authored several additional landmark articles exploring various aspects of TCR-pMHC interactions, including the first structure of a γδ TCR-pMHC complex, the molecular basis for dual recognition of "self" and "foreign" MHCs by TCRs, insights into the germline basis of TCR/MHC interactions, the extent of cross-reactivity in the TCR repertoire, and elucidation of the structural trigger for TCR signaling.
• T cell precursors extravasate from the bloodstream in cortico-medullary junction and they first migrate to the thymic cortex, where they undergo construction of TCRs and subsequently a process called T cell positive selection which is mediated by mTEC-related cells: cortical thymic epithelial cells (cTECs).
• Superantigens can form this overexpression by controlling interactions between MHC-II and TCRs as well as increasing the B7-2 and CD28 costimulatory interactions.
• While cTECs control the functionality of TCRs during the process called positive selection, Medullary thymic epithelial cells (mTECs) that home in the inner part of the thymus- medulla, present on their MHC molecules self-peptides, generated mostly by protein Autoimmune regulator, to eliminate T cells with self-reactive TCRs via processes of central tolerance e.
• Antigen-presenting cells (APCs) of the thymus, namely medullary thymic epithelial cells (mTECs), dendritic cells (DCs) and B cells are capable to present peptides derived from TRAs to developing T cells (thymus is the major origin of T cell development) and hereby test, whether their T cell receptors (TCRs) engage self entities and therefore their occurrence in the body can potentially lead to the development of autoimmune disease.

Förberedelsen av sidan tog: 327,55 ms.