Synonymer & Information om | Engelska ordet THIOACETAMIDE

Exempel på hur man kan använda THIOACETAMIDE i en mening

• A well-known thioamide is thioacetamide, which is used as a source of the sulfide ion and is a building block in heterocyclic chemistry.
• Its administration in rat induces hepatic encephalopathy, metabolic acidosis, increased levels of transaminases, abnormal coagulation, and centrilobular necrosis, which are the main features of the clinical chronic liver disease so thioacetamide can precisely replicate the initiation and progression of human liver disease in an experimental animal model.
• The actual rearrangement reaction takes place when the amine group attacks the thiocarbonyl in a nucleophilic addition temporarily forming an aziridine and the thioacetamide by tautomerization.
• Centrilobular necrosis (CN) is a nonspecific histopathological observation brought on by hepatotoxins like acetaminophen (paracetamol), thioacetamide, tetrachloride, Centrilobular necrosis can also be found in those with autoimmune hepatitis.

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