Information om | Engelska ordet THROMBOPOIETIN

Exempel på hur man kan använda THROMBOPOIETIN i en mening

• This may result in unwanted immunogenicity, including ADAs and autoimmune diseases, such as autoimmune thrombocytopenia (ITP) following exposure to recombinant thrombopoietin and pure red cell aplasia, which was associated with a particular formulation of erythropoietin (Eprex).
• Some of them are currently in clinical use: romiplostim, eltrombopag, oprelvekin (a recombinant interleukin 11) and thrombopoietin.
• The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene.
• Other strategies for managing patients with platelet refractoriness who require procedures include thrombopoietin receptor agonists, complement inhibitors such as eculizumab, and slow infusion.
• The cause of CAMT is believed to be mutations in the MPL gene coding for thrombopoietin receptor, which is expressed in pluripotent hematopoietic stem cells and cells of the megakaryocyte lineage.
• In recent years his group has established that thrombopoietin exerts a profound influence on hematopoietic stem cells, affects the expression of a number of transcription factors that influence stem cell fate decisions (HOXB4, HOXA9, c-Myb, HIF1A) and has unraveled the pathobiology of several congenital disorders of thrombopoiesis.
• Thrombopoietin mimetics are drugs that considerably increase platelet production by stimulating the receptor for the hormone thrombopoietin; Romiplostim and Eltrombopag are examples.
• They were able to show with Françoise Wendling that the orphan MPL receptor had as ligand a megakaryopoiesis stimulating factor that had all the characteristics of thrombopoietin, a presumptive humoral factor that physiologically regulates platelet production.

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