Synonymer & Anagram | Engelska ordet TRANSLOCON

Exempel på hur du använder TRANSLOCON i en mening

• The translocon (also known as a translocator or translocation channel) is a complex of proteins associated with the translocation of polypeptides across membranes.
• If the sequence is at the end of the polypeptide, it is cleaved off after entering the ER-lumen (via a translocon) by a signal peptidase, and subsequently degraded.
• N-linked glycosylation occurs as soon as the protein sequence passes into the ER through the translocon, where it is glycosylated with a sugar molecule that forms the key ligand for the lectin molecules calreticulin (CRT; soluble in ER lumen) and calnexin (CNX; membrane bound).
• It is now clear that some effectors, collectively named translocators, are secreted first and produce a pore or a channel (a translocon) in the host cell membrane, through which other effectors may enter.
• He studies several aspects of cellular secretion, including the mechanisms by which newly synthesized proteins are translocated from the cytosol to the lumen of the endoplasmic reticulum by the Sec61 complex (also known as the translocon), how misfolded secretory proteins are degraded by endoplasmic reticulum associated protein degradation (also known as ERAD), and how reticulons and related proteins regulate the morphology of the endoplasmic reticulum.
• It regulates the activation of MITA, a central adaptor protein in the innate immune response to DNA viral infections that activates and onsets the antiviral response, by allowing its association with the class III phosphatylinositol 3 kinase VPS34-containing translocon machinery to form the MITA-Vps34 translocation complex; this linkage is crucial for MITA transport from the ER to perinuclear microsomal punctuate structures, which are induced by infection of viruses such as HSV-1, via Golgi mediated intracellular traffic.
• It was found that OT binds the ribosome, and the Sec61 translocon complex binds the ribosome as well to form a complex to glycosylate N-linked oligosaccharides on proteins translocating into the endoplasmic reticulum.

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