Information om | Engelska ordet TRIFLUOROMETHYL

Exempel på hur man kan använda TRIFLUOROMETHYL i en mening

• Compounds with large electronegative groups such as trifluoromethyl can form supramolecular associations or aggregates or clusters in which these groups are separated from each other as much as possible with minimized electrostatic repulsions.
• The trifluoromethyl group has a significant electronegativity that is often described as being intermediate between the electronegativities of fluorine and chlorine.
• The trifluoromethyl phenyl moiety cements the thermodynamic favorability of the inactive conformation when the kinase domain is bound to BAY43-9006 by sterically blocking the hydrophobic pocket between the αC and αE helices that the DFG motif and activation loop would inhabit upon shifting to their locations in the active conformation of the protein.
• Later a trifluoromethyl ketone (3-octylthio-1,1,1-trifluoro-2-propanone) was shown to be a highly potent, high affinity slow, tight binding inhibitor of the JH esterase of Trichoplusia ni, the same Lepidopteran which was used in the other study in this section.
• The first breakthrough was made when a trifluoromethyl group was used to replace one of the chlorines in cypermethrin, especially when the double bond was in its Z form.
• Together with t-butyl hydroperoxide, an oxidant, this compound was found to be a suitable reagent for introducing trifluoromethyl groups onto electron-rich aromatic compounds by Langlois; this reagent is also known as the Langlois reagent.
• Several notable pharmaceutical compounds have a trifluoromethyl group incorporated: fluoxetine, mefloquine, Leflunomide, nulitamide, dutasteride, bicalutamide, aprepitant, celecoxib, fipronil, fluazinam, penthiopyrad, picoxystrobin, fluridone, norflurazon, sorafenib and triflurazin.
• Known sulfonyl nitrenes include methyl sulfonyl nitrene, trifluoromethyl sulfonyl nitrene, and tolyl sulfonyl nitrene.
• Examples include metal-free alkylation and arylation of benzothiophenes, metal-free synthesis of benzothiophenes by twofold C–H functionalization, and new reagents for metal-free C–H trifluoromethylthiolation in Trifluoromethyl sulfoxides.

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