Anagram & Information om | Engelska ordet TUBULIN

Exempel på hur man kan använda TUBULIN i en mening

• Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells.
• In contrast, tubulin polymers (microtubules) tend to be much bigger than actin filaments due to their cylindrical nature.
• Neural cells, for example, express growth-associated proteins, such as GAP-43, tubulin, actin, an array of novel neuropeptides, and cytokines that induce a cellular physiological response to regenerate from the damage.
• Rab GTPases regulate many steps of membrane trafficking, including vesicle formation, vesicle movement along actin and tubulin networks, and membrane fusion.
• HDAC6 deacetylates tubulin, Hsp90, and cortactin, and forms complexes with other partner proteins, and is, therefore, involved in a variety of biological processes.
• The mitotic apparatus is made up of a central spindle and polar asters made up of polymers of tubulin protein called microtubules.
• At Princeton, his early work on microtubules established their unusual molecular assembly from tubulin proteins and identified the first microtubule-stabilizing protein tau, later shown to be a major component of the neurofibrillary tangles in Alzheimer's disease.
• This binding can occur with either polymerized or depolymerized tubulin, and in most cases leads to the stabilization of microtubule structure, further encouraging polymerization.
• The mitotic spindle is composed of microtubules (polymerized tubulin) that aid, along with regulatory proteins, each other in the activity of appropriately segregating replicated chromosomes.
• At low concentrations of free tubulin, the growth rate at the microtubule ends is slowed and results in an increased rate of depolymerization (disassembly).
• Microtubules are essential to cell division, and taxanes stabilize GDP-bound tubulin in the microtubule, thereby inhibiting the process of cell division as depolymerization is prevented.
• The most commonly used normalizing genes are those that code for the following molecules: tubulin, glyceraldehyde-3-phosphate dehydrogenase, albumin, cyclophilin, and ribosomal RNAs.
• Once the motor reaches the end of the microtubule, the protofilament spontaneously curves itself allowing motor to make full contact with the tubulin subunit.
• Unlike the motility of actin-based cells, which is based on polar cytoskeletal elements such as actin monomers or tubulin dimers, nematode sperm locomotion is based on a pseudopod and a cytoskeleton built out of a meshwork of non-polar MSP filaments.
• In addition, neurofilaments, actin, and tubulin are often used to compare the resolving power of STED and confocal microscopes.
• Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials, epothilones have better efficacy and milder adverse effects than taxanes.
• It is known that Survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis.
• Analysis by immunofluorescence corroborated that NETs contain proteins from azurophilic granules (neutrophil elastase, cathepsin G and myeloperoxidase), specific granules (lactoferrin), tertiary granules (gelatinase), and the cytoplasm; however, CD63, actin, tubulin and various other cytoplasmatic proteins are not present in NETs.
• Of the natural products presently known combretastatin A-4 is the most potent in regards to both tubulin binding ability and cytotoxicity.
• Max Planck Fellow Simone Reber heads the group Quantitative Biology, where she works on the biochemical and biophysical principles that underlie the self-organization and scaling of organelles with a focus on the properties of tubulin.

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