Definition, Betydelse, Synonymer & Anagram | Engelska ordet CENTROSOME

Definition av CENTROSOME

1. centrosom

Exempel på hur man kan använda CENTROSOME i en mening

• A bound pair of centrioles, surrounded by a highly ordered mass of dense material, called the pericentriolar material (PCM), makes up a structure called a centrosome.
• In cell biology, the centrosome (Latin centrum 'center' + Greek sōma 'body') (archaically cytocentre) is an organelle that serves as the main microtubule organizing center (MTOC) of the animal cell, as well as a regulator of cell-cycle progression.
• Aster (cell biology), a cellular structure shaped like a star, formed around each centrosome during mitosis.
• A number of non-kinetochore microtubules or polar microtubules find and interact with corresponding nonkinetochore microtubules from the opposite centrosome to form the mitotic spindle.
• The first aurora kinases were identified in Drosophila melanogaster, where mutations led to failure of centrosome separation with the monopolar spindles reminiscent of the North Pole, suggesting the name aurora.
• "Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation", Journal of Cell Science 116, 2321-2332 (2003).
• Cyclin A binds to the mitotic spindle poles in the centrosome however, the mechanism by which the complex is shuttled to the centrosome is not well understood.
• CP110 is another cyclin E/CDK2 substrate which involves in centriole duplication and centrosome separation.
• Without Aurora A the centrosome does not accumulate the quantity of γ-tubulin that normal centrosomes recruit prior to entering anaphase.
• The γ-TuRCs in the centrosome nucleate an array of microtubules in interphase, which extend their (+)-ends radially outwards into the cytoplasm towards the periphery of the cell.
• Remarkably, the localisation and function of Polo kinase at the centrosome, the kinetochore and the central spindle in cytokinesis was highly conserved in human cells where its expression was elevated in tumours.
• DISC1 is localized to the centrosome, the primary microtubule organizing center of the cell, via interaction with nuclear distribution gene homologue-like 1 (NDEL1, also called NUDEL), where it is part of a protein complex involved in cytoskeletal processes of neuronal migration, including nucleokinesis and neurite outgrowth.
• In the C-lobe, furthermore, a nuclear localization signal (NLS) as well as a centrosome localization signal (CLS) can be found.
• During mitosis and cytokinesis, Plks associate with several structures including the centrosome, kinetochores, and the central spindle.
• Centrins, also known as caltractins, are a family of calcium-binding phosphoproteins found in the centrosome of eukaryotes.
• Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes.
• The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation.
• It is an integral component of the PCM, which is a centrosome scaffold that anchors microtubule nucleating complexes and other centrosomal proteins.
• Aurora C localizes to the centrosome and then to the midzone of mitotic cells from anaphase to cytokinesis.
• The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome.

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