Information om | Engelska ordet CENTROSOMES

Exempel på hur man kan använda CENTROSOMES i en mening

• In metaphase, microtubules from both duplicated centrosomes on opposite poles of the cell have completed attachment to kinetochores on condensed chromosomes.
• Kinetochore microtubules emerging from the centrosomes at the poles (ends) of the spindle reach the chromosomes and attach to the kinetochores, throwing the chromosomes into agitated motion.
• The asters are nucleated by centrosomes and the centrosomes are organized by centrioles brought into the egg by the sperm as basal bodies.
• The second 80 kDA subunit, encoded by KATNB1, regulates the activity of the ATPase and localizes the protein to centrosomes.
• Without Aurora A the centrosome does not accumulate the quantity of γ-tubulin that normal centrosomes recruit prior to entering anaphase.
• When the sperm cell fertilizes the egg cell, the sperm pronucleus and centrosomes are deposited within the egg, which causes a cytoplasmic flux resulting in the movement of the pronucleus and centrosomes towards one pole.
• These include the centrosomes in early M phase, the spindle midzone in early and late anaphase and the midbody during cytokinesis.
• ROCK1 has a ubiquitous tissue distribution, but subcellularly it is thought to colocalize with the centrosomes.
• Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes.
• NM-IIB is expressed early during embryonic development in cardiomyocytes, and appears to play a role in karyokinesis; ablation of NM-IIB caused defects in chromatid segregation and mitotic spindle formation, as well as abnormal structure of centrosomes.
• ” The mechanism of this localization currently remains unclear, but it is not RanGTP dependent despite its downfield position from RanGTP activity, as TPX2 in Xenopus laevis egg extracts have been shown to accumulate at the center of microtubule asters (after the addition of centrosomes, taxol, or DMSO) and bind to pure microtubules in the presence of importins.
• The PACT domain is responsible for targeting the protein to the centrosomes and attaching it to the centriole walls during interphase.
• The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis.
• During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes.
• Although ciliopathies are usually considered to involve proteins that localize to motile and/or immotile (primary) cilia or centrosomes, it is possible for ciliopathies to be associated with unexpected proteins such as XPNPEP3, which localizes to mitochondria but is believed to affect ciliary function through proteolytic cleavage of ciliary proteins.
• The FPC protein is also found on the centrosomes and mitotic spindle and may regulate centrosome duplication and mitotic spindle assembly during cell division.
• The centrosomes of the species, much like Marchantia polymorpha, are composed of two centrioles apposed end-to end, which are connected by a continuation of their cartwheel structures.
• Nucleophosmin is only found in unreplicated centrosomes and its phosphorylation by Cdk2/cyclin E removes NPM from the centrosomes, initiating procentriole formation.
• In most eukaryotic cells, Kinesin-5 is thought to form cross-bridges between pairs of oppositely oriented microtubules in prophase and prometaphase and drives apart duplicated centrosomes during the formation of the mitotic spindle.
• Plasmocytes; the survival of the centrosomes and archoplasm of the nucleated erythrocytes, as free and independent elements in the blood of Batrachoseps attenuatus Esch.

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