Information om | Engelska ordet GP120

Exempel på hur man kan använda GP120 i en mening

• Similarly to HIV-1 gp120 binding, both DC-SIGN and its homologue L-SIGN (CD209L or CD299) have also been identified as receptors facilitating the entry of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into human cells.
• The primary env product is the protein gp160, which gets cleaved to gp120 (~480 amino acids) and gp41 (~345 amino acids) in the endoplasmatic reticulum by the cellular protease furin.
• HIV-1 entry to macrophages and T helper cells is mediated not only through interaction of the virion envelope glycoproteins (gp120) with the CD4 molecule on the target cells but also with its chemokine coreceptors.
• Epigallocatechin gallate, a substance found in green tea, appears to interact with gp120 as do several other theaflavins.
• While natural anti-gp120 antibodies exhibit a response towards uninfected CD4-expressing cells that have a soluble gp120 bound to the CD4 on the cell surface, CD4 immunoadhesin, however, will not exhibit a response.
• N-butyldeoxynojirimycin interferes with the secretion of hepatitis B virus and reduces the infectivity of HIV virions, in the latter case by preventing proper folding of the gp160 precursor glycoprotein to cause a conformational defect in mature gp120, which interferes with the process of fusion with host membranes.
• Viral entry to the CD4+ cell begins with attachment of the R5 HIV-1 glycoprotein 120 (gp120) to the CD4+ T-cell receptor, which produces a conformational change in gp120 and allows it to bind to CCR5, thereby triggering glycoprotein 41 (gp41) mediated fusion of the viral envelope with the cell membrane and the nucleocapsid enters the host cell (Figure 1).
• His research group pioneered solving the crystal structures of CD4, CD8, insulin receptor kinase, Hsp70, SRC kinase, HIV gp120, cadherin, FGF and many other proteins that are key for understanding human disease and drug development.
• Kanmogne and her colleagues discovered that the HIV-1 envelope glycoprotein, gp120, activates the CCR5 and CXCR4 receptors on the surface of human brain microvasculature endothelial cells (HBMECs) leading to toxicity and BBB leakage.

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