Definition, Betydelse & Anagram | Engelska ordet IFN

Definition av IFN

1. (biokemi) förkortning för interferon

Exempel på hur du använder IFN i en mening

• As a result, flaviviruses and pseudo typed retroviruses have a harder time infecting TAM-deficient DCs, albeit infection can be brought back by type I IFN antibodies.
• The promoter region of PKR has interferon-stimulated response elements to which Type I interferons (IFN) bind to induce the transcription of PKR genes.
• Acemannan has been demonstrated to induce macrophages to secrete interferon (IFN), tumor necrosis factor-α (TNF-α) and interleukins (IL-1); therefore, it might help to prevent or abrogate viral infection.
• The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses.
• The evolutionary conservation of type I IFN subtypes binding the same IFNAR receptor at the same site with differing affinities suggests that type I IFNs are nonredundant and potentially regulate different cellular responses.
• NOD2 has also been shown to bind to MAVS in response to ssRNA or viral RNA treatment and activate the IFN response.
• IRF3 and IRF7 are themselves transcription factors that translocate into the nucleus and activate the transcription of type I IFNs genes and thereby initiate the process leading to the secretion of IFN by the infected cells.
• There are specific proteins produced by HPIV3 that induce mitophagy in the infected cell, thus promoting MAVS degradation and the corresponding inhibition of IFN I production.
• NLRP11 acts as a negative regulator of type I IFN and virus-induced apoptosis by disrupting the Mitochondrial antiviral-signaling protein (MAVS) signalosome activity.
• IFN merged with EntryPoint Technologies (formed when EntryPoint acquired PointCast) in 2001 to become Infogate, a real-time Internet proprietary financial news feed.
• In mice, paeoniflorin was shown to protect against neuroinflammation and depression-like behavior induced by IFN alpha.
• thumbIn humans, the virus has a strong tropism for nonciliated bronchial epithelial cells, and it has been shown to effectively evade the innate immune responses and antagonize interferon (IFN) production in these cells.
• The type 1 IFN response initiated by DCs, perhaps through recognition of phagocytosed DNA, has an important co-stimulatory effect.
• The IFN is also accredited to deliver international language certifications like: DELF, DALF, TCF, DELF Prim, DELF Junior and the TCF Québec.
• Induction of TRIM14 by type I IFN leads to activation of USP14 which then cleaves the polyubiquitin chain from cGAS and type I IFN signalling is stabilized.

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