Synonymer & Information om | Engelska ordet LIPOXYGENASE

Exempel på hur man kan använda LIPOXYGENASE i en mening

• A lipoxin (LX or Lx), an acronym for lipoxygenase interaction product, is a bioactive autacoid metabolite of arachidonic acid made by various cell types.
• However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.
• White blood cells are activated by upregulation of integrin avidity, the lipoxygenase pathway and arachidonic acid metabolism.
• Its biosynthesis starts from the fatty acid linolenic acid, which is oxygenated by lipoxygenase (13-LOX), forming a hydroperoxide.
• In addition to yielding anti-inflammatory eicosanoids, DGLA competes with AA for COX and lipoxygenase, inhibiting the production of AA's eicosanoids.
• Olsalazine thus exerts its anti-inflammatory effect by its colonic breakdown into 5-ASA which inhibits cyclooxygenase and lipoxygenase thereby reducing prostaglandin and leukotriene production.
• However, like the EFAs, it forms biologically active metabolites in the presence of cyclooxygenase or lipoxygenase.
• It inhibits both cyclooxygenase (COX-2) and lipoxygenase (5-LOX) enzymes suppressing biosynthesis of prostaglandins and leukotrienes, respectively.
• Biochemically, 1-octen-3-ol is generated from the peroxidation of linoleic acid, catalyzed by a lipoxygenase, followed by cleavage of the resulting hydroperoxide with the help of a hydroperoxide lyase.
• Samuelsson, and his famed colleague, Mats Hamberg, in 1974 by showing that human platelets metabolize arachidonic acid not only by the well-known cyclooxygenase pathway into prostaglandins and 12-hydroxyheptadecatrienoic acid but also by a cyclooxygenase-independent pathway to 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid; this activity was the first mammalian lipoxygenase activity to be characterized.
• This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides.
• The elaborate structural studies of proteins from several important systems as potential drug targets such as phospholipase A2, cyclooxygenase, lipoxygenase, endothelin receptor, endothelin converting enzyme, breast cancer regression proteins and matrix metanosomal proteins as well as their complexes with natural and designed synthetic ligands have been carried out.
• Inhibits free radicals during the synthesis of prostaglandin catalyzed cyclooxygenase and lipoxygenase, increases the correlation prostacyclin/ thromboxane A2 and blocks the leukotriene formation.
• Study shows that metabolites of the lipoxygenase pathway are involved with the antiproliferation induce by PUFA.
• The lipoxygenase converts alkene groups into hydroperoxides, which cleave by hydroperoxide lyase into the corresponding cis-aldehydes.
• Specialized pro-resolving mediators (SPM, also termed specialized proresolving mediators) are a large and growing class of cell signaling molecules formed in cells by the metabolism of polyunsaturated fatty acids (PUFA) by one or a combination of lipoxygenase, cyclooxygenase, and cytochrome P450 monooxygenase enzymes.
• Serial metabolism by two different lipoxygenases or by a lipoxygenase and a cytochrome P45 on a 1Z,4Z,7Z-PUFA may also make a 1,7-dihydroxy 2E,4Z,6E product.
• Other than being a potent antibiotic, PBP also demonstrates a wide variety of in vitro biological functions including antitumor activity, antifungal activity, myosin inhibition, human lipoxygenase inhibition, and phytotoxicity.

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