Definition, Betydelse, Synonymer & Anagram | Engelska ordet TLR
TLR
Definition av TLR
- (fysiologi) förkortning för Toll-like receptor, en viktig klass av membranbundna PRR:er inom det medfödda immunförsvaret
Antal bokstäver
3
Är palindrom
Nej
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Exempel på hur du använder TLR i en mening
- A twin-lens reflex camera (TLR) is a type of camera with two objective lenses of the same focal length.
- System cameras are often single-lens reflex (SLR) or twin-lens reflex (TLR) but can also be rangefinder cameras or, more recently, mirrorless interchangeable-lens cameras.
- The binding of ligands — either in the form of adjuvant used in vaccinations or in the form of invasive moieties during times of natural infection — to the TLR marks the key molecular events that ultimately lead to innate immune responses and the development of antigen-specific acquired immunity.
- These were TLR (Thanet), Medway FM (Medway Towns), Neptune Radio (Shepway and Dover), CTFM (Canterbury and district) and KFM (Tonbridge and Sevenoaks).
- CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS).
- Following a viral infection, pathogens are detected by Pattern Recognition Receptors (PRRs), including various types of Toll-like Receptors (TLR) and cytosolic PRRs, in the host cell.
- He was one of the three founders of Opsona Therapeutics in 2004; Opsona's research is primarily focused on the role of toll-like receptors (TLRs) and TLR signalling in human innate immunity.
- Over time, both the TLR and ATNR can cause serious damage to the growing child's joints and bones, causing the head of the femur to partially slip out of the acetabulum (subluxation) or completely move out of the acetabulum (dislocation).
- Expression of IL-15 can be stimulated by cytokine such as GM-CSF, double-strand mRNA, unmethylated CpG oligonucleotides, lipopolysaccharide (LPS) through Toll-like receptors (TLR), interferon gamma (IFN-γ) or after infection of monocytes herpes virus, Mycobacterium tuberculosis and Candida albicans (Figure 2).
- Over time, both the TLR and ATNR can cause serious damage to the growing child's joints and bones, causing the head of the femur to partially slip out of the acetabulum (subluxation) or completely move out of the acetabulum (dislocation).
- Expression of CD70 on mDCs and pDCs is induced with Toll-like receptor (TLR) triggering and CD40 ligation.
- Both the TLR and IL-1R mediate a signaling cascade that involves MyD88 binding to the receptor, oligomerization of the MyD88, recruitment of IRAK-1 via the DD, multimerization of IRAK-1, and ultimately kinase activation and further downstream signaling.
- Receptors such as toll-like receptors (TLR) and nod-like receptors (NLR) will activate the immune system by binding of ligands such as lipopolysaccharides and peptidoglycan.
- BLIMP-1 expression is also upregulated by danger signals from double-stranded RNA (specific to virus), lipopolysaccharides (specific to gram-negative bacteria), unmethylated CpG DNA (abundant in bacterial genomes), and cancer inflammation via Toll-like receptor (TLR) 3, TLR-4, TLR-9, and STAT signaling, respectively.
- TSLP mRNA expression is upregulated by certain Toll-like receptor (TLR) ligands such as flagellin and , but not by lipopolysaccharide (LPS) or macrophage-activating lipopeptide 2 (MALP-2).
- His research also combined genetic perturbations of sphingolipid metabolism with the quantification of diverse steps in TLR signaling and mass spectrometry-based lipidomics, which revealed that membrane lipid composition was affected by these perturbations.
- After ligand binding, the first step of IL-1R family signalling is oligomerization of TIR domains present on receptors (IL-1R, TLR), coreceptors (IL-1R accessory protein, CD14) and adaptor molecules (MyD88).
- M1-activation in vitro is evoked by treatment with TLR ligands such as bacterial lipopolysaccharide (LPS) - typical for Gram-negative bacteria and lipoteichoic acid (LTA) - typical for Gram-positive bacteria, granulocyte-macrophage colony-stimulating factor (GM-CSF) or combination of LPS and interferon-gamma (IFN-γ).
- After Belarusian President Alexander Lukashenko issued the decree which made cryptocurrencies a legal method of payment and the Taler (TLR) cryptocurrency was launched in Belarus, Taler was made the official currency of Veyshnoria.
- Several TLR immunodeficiencies have been described in which cellular proteins that should transmit the message from the TLRs to the nucleus are abnormal.
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